The Church of San Zaccaria is a 15th-century former monastic church in central Venice, Italy. It is a large edifice, located in the Campo San Zaccaria, just off the waterfront to the southeast of Piazza San Marco and St Mark's Basilica. It is dedicated to St. Zechariah, the father of John the Baptist.

The first church on the site was founded by Doge Giustiniano Participazio in the early 9th century to house the body of the saint to which it is dedicated, a gift of the Byzantine Emperor Leo V the Armenian, which it contains under the second altar on the right. The remains of various doges are buried in the crypt of the church. The original church was rebuilt in the 1170s (when the present campanile was built) and was replaced by a Gothic church in the 15th century. The remains of this building still stand, as the present church was built beside and not over it.

The present church was built between 1458 and 1515. Antonio Gambello was the original architect, who started the building in the Gothic style, but the upper part of the facade with its arched windows and its columns, and the upper parts of the interior were completed by Mauro Codussi in early Renaissance style many years later. The facade is a harmonious Venetian mixture of late-Gothic and Renaissance styles.